Which One Of The Following Statements Is True Regarding Transcription-coupled Repair?

Multiple Choice Question Set I on

Molecular Biology: DNA synthesis (Replication)

1) In most organisms, Dna is a genetic material that stores the data template for the synthesis of RNA and after protein.

Proper name the processes a, b, c represented in the effigy:

Key Dogma of Molecular Biological science

ii) In some viruses, RNA serves every bit the storage of genetic materials and DNA is synthesized from RNA by the enzyme known as:
a) Dna synthetase
b) Dna polymerase
c) Contrary transcriptase
d) Deoxyribonucleic acid convertase

3) Which of the following procedure does non occur in prokaryotes?

a) Replication

b) Splicing

c) Translation

d) Transcription

4) Phosphodiester bond links 2 nucleotides together and maintains polarity which refers to:

a) the 5' hydroxyl grouping of pentose of one nucleotide to 3' hydroxyl group of adjacent nucleotide through a phosphate grouping.
b) five' cease with a phosphate group and 3'stop with hydroxyl are free.
c) addition of new nucleotide occurs via attachment of five' phosphate group of new nucleotide to 3' phosphate group of an existing chain.
d) All of the above

5) Dna helices exist in various forms.

Which of the following form is predominantly expressed in cells?
a) B- Helix
b) A-Helix
c) E-Helix
d) Z-Helix

6) Which one of the post-obit statements is true regarding the DNA double-helical structure?
a) The Deoxyribonucleic acid double helix is coiled effectually a common axis known every bit the centrality of symmetry
b) The hydrophilic deoxyribose-phosphate backbone of each chain is on the outside.
c) The hydrophobic nitrogen bases are stacked inside.
d) All of the In a higher place

vii) The spatial organisation Dna helical structure creates a major and minor groove which are important for:
a) kinking and bending of the helical structure
b) providing recognition and binding sites for various Deoxyribonucleic acid binding proteins
c) All of Above
d) None of the Above

8) Aminoglycoside antibiotics such as kanamycin, tobramycin, neomycin are known inhibitors of Dna synthesis. It contains a cyclitol ring linked to five or vi-membered sugars by glycosidic bonds.

These antibiotics are:
a) Positively charged compound that to DNA and intercalates it.
b) Positively charged chemical compound that binds to DNA polymerase activity.
c) Negatively charged chemical compound to Deoxyribonucleic acid and denatures it.
d) Negatively charged chemical compound that binds to histones

9) The Chargaff rules land that the number of purines and pyrimidines are equal (A+G = T + C)in any double-stranded Dna molecule. Watson and Crick later solved the structure of DNA and nitrogen base pairings.

Which of the following base-pairing rule is true?
a) Adenine pairs with Guanine and Thymine pairs with Cytosine
b) Adenine pairs with Thymine and Guanine pairs with Cytosine
c) Adenine pairs with Cytosine and Guanine pairs with Thymine
d) Deoxyribonucleic acid base pairing is nonspecific

x) The DNA replication occurs in a semi-conservative mode which means:
a) Two girl cells with one consisting of double-helical parent DNA, others have newly synthesized Deoxyribonucleic acid.

b) Ii girl cells each consisting of i parental strand and 1 newly synthesized DNA.
c) Two daughters cells each consisting of one-half parental and another half newly synthesized Dna resulting from the crossover.
d) None of the to a higher place

eleven) Which of the following are the characteristic characteristic of DNA replication?
a) DNA replication is template-directed
b) DNA replication requires short RNA primers
c) Deoxyribonucleic acid replication is a highly accurate process
d) All of the To a higher place

12) In prokaryotes, DNA replication begins at a single site that is rich in AT nucleotide sequence, where two strands unwind and separate.

This ATP dependent process is catalyzed past a protein known as..................................?
a) DnaA poly peptide
b) Single-strand binding poly peptide
c) Dna polymerase
d) Topoisomerase

13) The brusque strand of .......................... primer is required for the replication of DNA:
a) Deoxyribonucleic acid
b) RNA
c) Histone
d) hnRNA

xiv) Every bit the two strands of the double helix are separated, the positive supercoiling interferes with the further unwinding of Dna.

Which of the post-obit enzyme makes a suspension in a strand of DNA to release the supercoiling and facilitate the replication to occur?
a) DnaA protein
b) Unmarried-strand binding protein
c) Dna polymerase
d) Topoisomerase

15) Which of the post-obit enzyme has a unique power to introduce positive and negative supercoiling of the DNA and it is the target for antibacterial agents such as ciprofloxacin/quinolones?
a) DnaA protein
b) Dna helicase
c) DNA gyrase
d) Dna polymerase

xvi) Dna replication is bidirectional and anti-parallel.

Which of the statement is FALSE regarding Dna replication?
a) The DNA synthesis i.due east. addition of nucleotide occurs from five'-three' position
b) The DNA synthesis is semi-continuous with continuous leading strand and discontinuous lagging strand.
c) The synthesis of leading and lagging strands occurs simultaneously
d) None of the Above

17) The Dna polymerase is a template-directed enzyme that synthesizes a new complementary strand from a parent strand but information technology requires the existing brusk nucleotide sequence for its elongation.

Which of the following enzyme is required for the synthesis of this primer?
a) Primase/RNA polymerase
b) RNA synthase
c) DNA synthase
d) Helicase

xviii) Deoxyribonucleic acid polymerase Iii holoenzyme possesses:
a) polymerase activity simply
b) 3'→ 5' endonuclease activeness
c) 3'→ 5' exonuclease activeness and polymerase activities
d) 5'→ 3' exonuclease activity

19) Which of the following argument is truthful regarding an enzyme Deoxyribonucleic acid polymerase that catalyzes the elongation of complementary Dna strand?

a) Dna polymerase Three is a highly processive enzyme.
b) Deoxyribonucleic acid polymerase Iii possesses 5'-3' polymerase activity required for elongation.
c) DNA polymerase 3 possesses three'-5' exonuclease activeness important for maintaining allegiance
d) All of the higher up

20) In prokaryotes, the RNA primer from the lagging strand is removed and replaced past the Deoxyribonucleic acid sequence.

This procedure is catalyzed by an enzyme ..................................................which possess 5'-3' exonuclease activity and 5'-3' polymerase activeness.
a) DNA polymerase I
b) Deoxyribonucleic acid polymerase II
c) Dna polymerase 3
d) Deoxyribonucleic acid polymerase Iv

21) In eukaryotes, Deoxyribonucleic acid polymerase blastoff is a multi-subunit enzyme with different functions. They include..........................................................?
a) Elongation of the leading strand
b) 3'-v' exonuclease activeness
c) Initiation and synthesis of RNA primer
d) High processivity

22) In eukaryotes, which of the following DNA polymerase is highly processive and required for the elongation stage of DNA replication?
a) Pol alpha
b) Pol delta
c) Political leader gamma
d) Pol beta

23) In eukaryotes, which of the following Deoxyribonucleic acid polymerase is required for mitochondrial DNA replication?
a) Politico alpha
b) Pol beta
c) Pol gamma
d) Politico delta

24) Telomeres are the repetitive sequence of T'south and G's that are nowadays in the eukaryotes to protect the random cleavage from nucleases. These telomeres are synthesized by the enzyme telomerase.

Which of the following are the properties of enzyme telomerase?
a) Telomerase is a reverse transcriptase enzyme
b) Telomerase consist of an RNA sequence that serves as a template
c) Later on completion of each bicycle, telomerase translocates to iii'end of Deoxyribonucleic acid to synthesize repetitive sequence.
d) All of the in a higher place

Multiple Choice Answers:

1- a)- Replication, b-Transcription, c- Translation

2- c) Opposite transcriptase

three- b) Splicing

four- d) All of the above

7- b) providing recognition and bounden sites for various Deoxyribonucleic acid bounden proteins

eight- a) Positively charged compound that to Deoxyribonucleic acid and intercalates information technology

ix- b) Adenine pairs with Thymine and Guanine pairs with Cytosine
ten- b) Two girl cells each consisting of 1 parental strand and one newly synthesized DNA

17- a) Primase/RNA polymerase

eighteen- c) 3'→ 5' exonuclease activity and polymerase activities

21- c) Initiation and synthesis of RNA primer

Which One Of The Following Statements Is True Regarding Transcription-coupled Repair?,

Source: https://www.medicalbiochemist.com/2018/04/molecular-biology-mcq.html

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